1993年

Endoh M, Yamashina M, Ohi H, Funabashi K, Ikuno T, Yasugi T, Atkinson JP, and Okada H.
Immunohistochemical demonstration of membrane cofactor protein (MCP) of complement in normal and diseased kidney tissues.
Clin Exp Immunol 1993 Oct;94(1):182-8

TOPへ 

 
1994年

Funabashi K, Okada N, Matsuo S, Morgan BP, and Okada H.
Tissue distribution of complement regulatory membrane proteins in rats.
Immunology 1994 Mar;81(3):444-51

Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, and Yamamoto T.
Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissue.
Brain Res 1994 Sep 26;658(1-2):163-7

Baranyi L, Okada N, Baranji K, Takizawa H, and Okada H.
Membrane bound complement regulatory activiy is decreased on vaccinia virus infected cells.
Clin Exp Immunol 1994 Oct;98(1):134-9

Baranyi L, Baranji K, Yoshida T, Okada N, and Okada H.
Partial characterization of a low molecular weight phagocytosis inhibitory factor obtained from human erythrocyte membranes.
Immunobiology 1994 Dec;192(1-2):94-105

Baranyi L, Del Carpio C, Campbell W, and Okada H.
Design of antisense peptides using evolutionary algorithm.
Congress Abstract of Japanese Society of Chemistry, p.326, Tokyo 1994

赤津裕康、岡田秀親
自己免疫疾患とアポトーシス(総論)
最新医学・第49巻・第6号;1124-1130(1994)

中島捷久、信澤枝里、岡田秀親、中島節子、高橋三津雄、山田達夫
インフルエンザAウイルスの神経病原性
日本臨床免疫学会会誌(1994, 17-6:772-775)

TOPへ 

 
1995年

Yamada T, Yoshiyama Y, Sato H, Seiki M, Shinagawa A, and Takahashi M.
White matter microglia produce membrane -type matrix metalloprotease, an activater of gelatinase A, in human brain tissue.
Acta Neuropathol (Berl) 1995;90(5):421-4

Mitake S, Ojika K, Katada E, Otsuka Y, Matsukawa N, and Fujimori O.
Accumulation of hippocampal cholinergic neurostimulating peptide(HCNP)-related componennts in Hirano bodies.
Neuropathol Appl Neurobiol 1995 Feb;21(1):35-40

Wu X, Akatsu H, and Okada H.
Apoptosis of HIV-infected cells following treatment with Sho-saiko-to and its components.
Jpn J Med Sci Biol 1995 Apr;48(2):79-87

Higuchi K, Aoki K, Kimbara T, Hosoi N, Yamamoto T, and Okada H.
Suppression of natural killer cell activity by monocytes following immunotherapy for recurrent spontanous aborters.
Am J Reprod Immunol 1995 Mar;33(3):221-7

Jaossy T, Baranyi L, Vizler Cs, Nyirai I, and Veh P.
Induction of neonatal transplantation tolerance and lymphoprolypherative disorders in mice:The role of F1 donor cells.
Transplant Proc 1995 Feb;27(1):188-90

Takahashi M, Yamada T, Nakajima S, Nakajima K, Yamamoto T,and Okada H.
The substantia nigra is a major target for neurovirulent influenza A virus.
J Exp Med 1995 Jun 1;181(6):2161-9

Baranyi L, Campbell W, Ohshima K, Fujimoto S, Boros M, and Okada H.
The antisense homology box: a new motive in proteins that often codes biologically active peptides.
Nat Med 1995 Sep;1(9):894-901

Yamada T, Miyazaki K, Koshikawa N, Takahashi M, Akatsu H,and Yamamoto T.
Selective localization of gelatinase A, an enzyme degrading b-amyloid protein, in white matter microglia and in Schwann cells.
Acta Neuropathol (Berl) 1995;89(3):199-203

Ojika K, Katada E, Tohdoh N, Mitake S, Otsuka Y, Matsukawa N, and Tsugu Y.
Demonstration of deacetyiated hippocampal cholinergic neurostimulating peptide and its protein in rat tissue.
Brain Res 1995 Dec 1;701(1-2):19-27

TOPへ 

 
1996年

Katada E, Mitake S, Matsukawa N, Otsuka Y, Tsugu Y, Fujmori O, and Ojika K.
Distribution of hippocampal cholinergic neurostimulating peptide (HCNP)-like immunoreactivity in organs and tissues of young Wistar rats.
Histochem Cell Biol 1996 Jan;105(1):43-51

Mitake S, Ojika K, Katada E, Otsuka Y, Matsukawa N, and Fujimori O.
Distribution of hippocampal cholinerggic neurostimulating peptide (HCNP) immunoreactivity in the central nervous system of the rat.
Brain Res 1996 Jan 8;706(1):57-70

Takahashi M, Yamada T, Tooyama I, Moroo I, Kimura H, Yamamoto T, and Okada H.
Insulin receptor mRNA in the substantia nigra in Parkinson's disease.
Neurosci Lett 1996 Feb 9;204(3):201-4

Fukuoka Y, Yasui A, Okada N, and Okada H.
Molecular cloning of murine decay accelerating factor (DAF) by immunoscreening.
Int Immunol 1996 Mar;8(3):379-85

Akatsu H, Yamada T, Okada N, Yamamoto T, Yamashina M, and Okada H.
HRF20(CD59) expresses in Human Nervous Tissue.
Mol. Immunology, Abstr., 33, p45. (1996)

Akatsu H, Vanmechelen E, Ongena L, Yamamoto T, Yamada T, and Okada H.
Characterization of Tau in Cerebrospinal Fluids (CSF) of Neuropathological Confirmed Alzheimer cases.
Neurobiol. Aging, Abstr., 17, p166, 1996

Mitake S, Katada E, Otsuka Y, Matsukawa N, Iwase T, Tsugu Y, Fujimori O, and Ojika K.
Possible implication of hippocampal cholinergic neurostimulating peptide (HCNP)-related components i Hirano body formation.
Neuropathol Appl Neurobiol 1996 Oct;22(5):440-5

Baranyi L, Campbell W, and Okada H.
Antisense homology boxes in C5a receptor and C5a anaphylatoxin. A new method for identification of potentially active peptides.
J Immunol 1996 Nov 15;157(10):4591-601

TOPへ 

 
1997年

Akatsu H, Yamada T, Okada N, Yamamoto T, Yamashina M, and Okada H.
Unique expression of HRF20 (CD59) in human nervous tissue.
Microbiol Immunol 1997;41(4):321-9

Takahashi M, Yamada T, Nakanishi K, Fujita K, Nakajima K, Nobusawa E, Yamamoto T, Kato T, and Okada H.
Influenza A virus infection of primary cultured cells from rat fetal brain.
Parkinsonism Relat Disord. 1997 Apr;3(2):97-102.

Akatsu H, Miwa T, Sakurade C, Fukuoka Y, Ember JA, Yamamoto T, Hugli TE, and Okada H.
cDNA cloning and characterization of rat C5a anaphylatoxin receptor.
Microbiol Immunol 1997;41(7):575-80

Kanie J, Kono K, Yamamoto T, Akatsu H, and Iguchi A.
[Gastro-esophageal reflux successfully treated with transgastrostomal jejunal tubefeeding].
Nippon Ronen Igakkai Zasshi 1997 Jan;34(1):60-4

蟹江治郎、河野和彦、山本孝之、赤津裕康、井口昭久
胃食道逆流のある高齢者に対しTGJ tube(Transe Gastrostomal Jejunal tube:経胃瘻的空腸栄養チューブ)を用いた経管栄養管理により在宅管理が可能になった1例
日本老年医学会誌 第34巻第1号 p.60-64 1997/01

TOPへ 

 
1998年

Boros M, Massberg S, Baranyi L, Okada H, and Messmer K.
Endothelin 1 induces leukocyte adhesion in submucosal venules of the rat small intestine.
Gastroenterology 1998 Jan;114(1):103-14

Farkas I, Baranyi L, Takahashi M, Fukuda A, Liposits Z, Yamamoto T, and Okada H.
Neuronal C5a receptor and an associated apoptotic signal transduction pathway.
J Physiol 1998 Mar 15;507 ( Pt 3):679-87

Farkas I, Baranji L, Takahashi M, Fukuda A, Yamamoto T, and Okada H.
Neuronal C5a receptor and an associated apoptotic signal transduction pathway.
J Physiol 1998 Mar 15;507 ( Pt 3):679-87

Baranyi L, Campbell W, Ohshima K, Fujimoto S, Boros M, Kaszaki J, and Okada H.
Antisense homology box derived peptides represent a new class of endothelin receptor inhibitors.
Peptides 1998;19(2):211-23

Watanabe M, Ishikawa Y, Campbell W, and Okada H.
Measurement of arginine carboxypeptidase-generating activity of adult plasma.
Microbiol Immunol 1998;42(5):393-7

Kanie J, Kono K, Yamamoto T, Akatsu H, Shimokata H, and Iguchi A.
Usefulness and problems of percutaneous endoscopic gastrostomy in a geriatric hospital
Nippon Ronen Igakkai Zasshi 1998 Jul;35(7):543-7

Farkas E, Baranyi L, Takahashi M, Fukada A, Liposits Zs, Yamamoto T, Okada H.
C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells.
Neuroscience 1998 Oct;86(3):903-11

Kanie J, Shimokata H, Akatsu H, Yamamoto T, Iguchi A.
Complications Following Percutaneous Endoscopic Gastrostmy: Acute Respiratory Infection and Local Skin Infection.
Dig. Endsc.;10:205-210.(1998)

Baranyi L, Ohshima K, Fujimoto S, Kaszaki J, Campbell W, Boros M, Okada N, and Okada H.
Antisense homology Box derived peptides represent a new class of Endothelin receptor inhibitors.
Peptides 1998;19(2):211-23

Tsuboi Y, Takahashi M, Ishikawa Y, Okada H, and Yamada T.
Elevated bradykinin and decreased carboxypeptidase R as a cause of hypotension during tryptophan column immunoabsorption therapy.
Ther Apher. 1998 Nov;2(4):297-9.

蟹江治郎、河野和彦,山本孝之、赤津裕康,下方浩史,井口昭久
老人病院における経皮内視鏡的胃瘻造設術の問題と有用性
日本老年医学会誌 1998; 35(7): 543-547 1998/07

Kanie J, Shimokata H, Akatsu H, Yamamoto T, Iguchi A
Risk Factors for Complication Following Percutaneous Endoscopic Gastrostomy: Acute Respiratory Infection and Local Skin Infection
Digestive Endoscopy 1998; 10(3): 205-210 1998/07

Takahashi M, Akatsu H, Tsujioka Y, Yamamoto T, Tsuboi Y, Yamada T, Okada H
Detection of Borna Disease Virus Antigen and RNA in human autopsy brain samples from patients with dementia
NEUROBIOLOGY OF AGING 1998; 19(S),abstract:1137

Akatsu H, E.Vanmechelen, L.Ongena, Yamamoto T, Okada H
Increase of CSF tau levels in clinically and neuropathologically diagnosed Alzheimer cases
NEUROBIOLOGY OF AGING 1998; 19(S),abstract:690

Kanie J, Akatsu H, Yamamoto T, Shimokata H, Iguchi A
Experience of percutaneous endoscopic gastrostomy in Alzheimer's disease and senile dementia of the Alzheimer's type cases
NEUROBIOLOGY OF AGING 1998; 19(4S): 21 1998/07-08

TOPへ 

 
1999年

Matsukawa N, Tooyama I, Kimura H, Yamamoto T, Tsugu Y, Oomura Y, and Ojika K.
Increased expression of hippocampal cholinergic neurostimulating peptide (HCNP)-related components and mRNA in the hippocampus of aged senescence accelerated mice (SAM).
Neuroscience 1999 Jan;88(1):79-92

Takahashi M, Tsujioka Y, Yamada T, Tsuboi Y, Okada H, Yamamoto T, and Liposits Z.
Glycosylation of microtubule-associated protein tau in Alzheimerユs disease brain.
Acta Neuropathol (Berl) 1999 Jun;97(6):635-41

Imre F, Baranyi L, Kaneko Y, Liposits Z, Yamamoto T, and Okada H.
C5a receptor expression by TGW neuroblastoma cells.
Neuroreport 1999 Sep 29;10(14):3021-5

TOPへ 

 
2000年

Oshima T, Okada N, Joh T, Sasaki M, Tada T, Matsukawa N, Nomura T, Ohara H, Itoh M, and Okada H.
Decay-accelerating factor in guinea pig stomachs following ishemia reperfusion stress.
J Immunol. 2000 Jan 15;164(2):1078-85.

Horimoto Y, Aiba I, Yasuda T, Ohkawa Y, Katayama T, Yokokawa Y, Goto A, and Ito Y
Cerebral atrophy in multiple system atrophy by MRI
J Neurol Sci 2000 Feb 15;173(2):109-12

Umegaki H, Ikari H, Nakahata H, Yoshimura J, Endo H, Yamamoto T, and Iguchi A.
Low plasma epinephrine in elderly female subjects of dementia of Alzheimer type.
Brain Res 2000 Mar 6;858(1):67-70

Kanie J, Kono K, Kono T, Osawa M, Yamamoto T, Akatsu H, Shimokata H, and Iguchi A.
[Complications of percutaneous endoscopic gastrostomy in the elderly: local skin infection and respiratory infection].
Nihon Ronen Igakkai Zasshi. 2000 Feb;37(2):143-8.

Kato T, Akatsu H, Sato T, Matsuo S, Yamamoto T, Campbell W, Hotta N, Okada N, and Okada H.
Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N.
Microbiol Immunol 2000;44(8):719-28

Sato T, Miwa T, Akatsu H, Matsukawa N, Obata K, Okada N, Campbell W, and Okada H.
Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not.
J Immunol 2000 Jul 15;165(2):1053-8

Ogawa K, Yamada T, Tsujioka Y, Taguchi J, Takahashi M, Tsuboi Y, Fujino Y, Nakajima M, Yamamoto Y, Akatsu H, Mitsui S, and Yamaguchi N.
Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease.
Psychiatry Clin Neurosci. 2000 Aug;54(4):419-26.

Umegaki H, Ikari H, Nakahata H, Endo H, Suzuki Y, Ogawa O, Nakamura A, Yamamoto T, and Iguchi A.
Plasma cortisol levels in elderly female subjects with Alzheimer's disease: acrosssectional and longitudinal study.
Brain Res 2000 Oct 27;881(2):241-3

Dean YD, McGreal EP, Akatsu H, Gasque P.
Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin.
J Biol Chem. 2000 Nov 3;275(44):34382-92.

蟹江治郎、河野和彦、河野勤、大澤雅子、山本孝之、赤津裕康、下方浩史、井口昭久
高齢者に対する経皮内視鏡的胃瘻造設術における合併症:創部感染症と呼吸器感染症の検討
日本老年医学会誌 2000; 37: 143-148 2000/04

蟹江治郎、河野勤、大澤雅子、赤津裕康、山本孝之、下方浩史、井口昭久
経皮内視鏡的胃瘻造設術術後、経管栄養を離脱し得た症例に対しての検討
在宅治療と内視鏡治療 4: 13-17 2000

TOPへ 

 
2001年

Masumura M, Hata R, Akatsu H, Kosaka K, Yamamoto T Nagai Y, and Sawada T.
Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease.
J Stroke Cerebrovasc Dis. 2001 Mar-Apr;10(2):55-62.

Abe M, Shibata K, Akatsu H, Shimizu N, Sakata N, Katsuragi T, and Okada H.
Contribution of anaphylatoxin C5a to late airway responses following repeated exposure of antigen to allergic rats.
J Immunol 2001 Oct 15;167(8):4651-60

Hata R, Masumura M, Akatsu H, Li F, Fujita H, Nagai Y, Yamamoto T,Okada H, Kosaka K, Sakanaka M, and Sawada T.
Up-Regulation of Calcineurin Abeta mRNA in the Alzheimer's Disease Brain: Assessment by cDNA Microarray.
Biochem Biophys Res Commun. 2001 Jun 8;284(2):310-6.

堀本佳彦、松本光弘、赤津裕康、伊苅弘之、山本孝之、小阪憲司、大塚康史、上田龍三、小鹿幸生
レビー小体病剖検例の臨床像
第101回日本神経学会東海北陸地方会
TOPへ 

 
2002年

Heese K, Nakayama T, Hata R, Masumura M, Akatsu H, Li F, Nagai Y, Yamamoto T, Kosaka K, Suemoto T, and Sawada T.
Characterizing CGI-94 (comparative gene identification-94) which is down-regulated in the hippocampus of early stage Alzheimer's disease brain
Eur J Neurosci 2002 Jan;15(1):79-86

Umegaki H, Ushida C, Ikari H, Ogawa O, Nakamura A, Suzuki Y, Endo H, Akatsu H, Yamamoto T, Iguchi A.
Plasma insulin and glucose levels in elderly female subjects with Alzheimer’s disease
Geriatrics and Gerontology International Volume 2, Issue 2, pages 75–79, March 2002

Ikeguchi H, Maruyama S, Morita Y, Fujita Y, Kato T, Natori Y, Akatsu H, Campbell W, Okada N, Okada H, Yuzawa Y, Matsuo S.
Effects of human soluble thrombomodulin on experimental glomerulonephritis.
Kidney Int 2002 Feb;61(2):490-501

Maki M, Matsukawa N, Yuasa H, Otsuka Y, Yamamoto T, Akatsu H, Okamoto T, Ueda R, Ojika K.
Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease.
J Neuropathol Exp Neurol 2002 Feb;61(2):176-85

Iseki E, Tsunoda S, Suzuki K, Takayama N, Akatsu H, Yamamoto T, Kosaka K.
Regional quantitative analysis of NFT in brains of non-demented elderly persons: comparisons with findings in brains of late-onset Alzheimer's disease and limbic NFT dementia.
Neuropathology 2002 Mar;22(1):34-9

Akatsu H, Takahashi M, Matsukawa N, Ishikawa Y, Kondo N, Sato T, Yamada T, Okada H, Yamamoto T, Kosaka K.
Subtype analysis of neuropathologically diagnosed patients in a Japanese geriatric hospital.
J Neurol Sci 2002 Apr 15;196(1-2):63-9

McGreal EP, Ikewaki N, Akatsu H, Morgan BP, Gasque P.
Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q.
J Immunol 2002 May 15;168(10):5222-32

Maeda S, Takeyama H, Okada H, Manabe T.
MUC1 Mucin Directly Binds to Tissue Culture Plates and Is Detectable with Antibody to MUC1 Core Protein
Nagoya medical journal 45(4), 159-170, 2002-04-30

Farkas I, Baranyi L, Ishikawa Y, Okada N, Bohata C, Budai D, Fukuda A, Imai M, Okada H.
CD59 blocks not only the insertion of C9 into MAC but inhibits ion channel formation by homologous C5b-8 as well as C5b-9.
J Physiol. 2002 Mar 1;539(Pt 2):537-45.

蟹江治郎、赤津裕康、山本孝之、葛谷雅文、井口昭久
Pull法またはPush法による経皮内視鏡的胃瘻造設術手技の工夫 -チューブ位置確認を目的とした内視鏡再挿入の必要性に対する検討-
在宅治療と内視鏡治療 6: 17-20 2002

Kanie J, Akatsu H, Suzuki Y, Shimokata H, Iguchi A.
Mechanism of the development of gastric ulcer after percutaneous endoscopic gastrostomy.
Endoscopy. 2002 Jun;34(6):480-2.

Kanie J, Akatsu H, Suzuki Y, Shimokata H, Iguchi A.
Mechanism of the development of gastric ulcer after percutaneous endoscopic gastrostomy
Endoscopy. 2002 Jun;34(6):480-2.
Kanie J, Kaganu C, Yamamoto T, Akatsu H, Suzuki Y, Kuzuya M, Igucgi A.
[Half-solid enteral nutrient prevents chronic complications of percutaneous endoscopic gastrostomy tube feeding]
Nippon Ronen Igakkai Zasshi 2002 Jul;39(4):448-51

Akatsu H, Abe M, Miwa T, Tateyama H, Maeda S, Okada N, Kojima K, Okada H.
Distribution of Rat C5a Anaphylatoxin Receptor.
Microbiol Immunol 2002;46(12):863-874


蟹江治郎、赤津裕康、山本孝之、葛谷雅文、井口昭久
Pull法またはPush法による経皮内視鏡的胃瘻造設術手技の工夫 - チューブ位置確認を目的とした内視鏡再挿入の必要性に対する検討 -
在宅治療と内視鏡治療 2002 Vol.6 17-20

蟹江治郎、各務千鶴子、山本孝之、赤津裕康、鈴木裕介、葛谷雅文、井口昭久
固形化経腸栄養剤の投与により胃瘻栄養の慢性期合併症を改善し得た1例
日本老年医学会誌 2002; 39: 448-451

Tsuboi Y, Kakimoto K, Akatu H, Daikuhara Y, Yamada T.
Hepatocyte growth factor in cerebrospinal fluid in neurologic disease.
Acta Neurol Scand 2002 Aug;106(2):99-103

Matsumoto M, Kosaka K, Horimoto Y, Akatsu H, Yamamoto T, Matsukawa N, Ueda R, Ojika K.
A Clinicopathological Study of Idiopathic Normal Pressure Hydrocephalus
Volume 2, Issue 4, pages 289–294, December 2002


TOPへ 

 
2003年

Tsuboi Y, Kakimoto K, Nakajima M, Akatsu H, Yamamoto T, Ogawa K, Ohnishi T, Daikuhara Y, Yamada T.
Increased hepatocyte growth factor level in cerebrospinal fluid in Alzheimer's disease.
Acta Neurol Scand. 2003 Feb;107(2):81-6.

Lu Q, Kanai Y, Kubota T.
The emergence of anti-dsDNA antibodies precedes nucleosome-specific antibodies in MRL/lpr and MRL/+ mice.
J Med Dent Sci. 2003 Mar;50(1):9-15.

Iseki E, Togo T, Suzuki K, Katsuse O, Marui W, de Silva R, Lees A, Yamamoto T, Kosaka K.
Dementia with Lewy bodies from the perspective of tauopathy.
Acta Neuropathol (Berl). 2003 Mar;105(3):265-70. Epub 2002 Nov 22.

Togo T, Iseki E, Shoji M, Oyama I, Kase A, Uchikado H, Katsuse O, Kosaka K.
Prolactin levels in schizophrenic patients receiving perospirone in comparison to risperidone.
J Pharmacol Sci. 2003 Mar;91(3):259-62.

Katsuse O, Iseki E, Kosaka K.
Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies.
Neuropathology. 2003 Mar;23(1):9-15.

Kishida I, Kawanishi C, Furuno T, Matsumura T, Hasegawa H, Sugiyama N, Suzuki K, Yamada Y, Kosaka K.
Lack of association in Japanese patients between neuroleptic malignant syndrome and the TaqI A polymorphism of the dopamine D2 receptor gene.
Psychiatr Genet. 2003 Mar;13(1):55-7.

Suzuki K, Iseki E, Katsuse O, Yamaguchi A, Katsuyama K, Aoki I, Yamanaka S, Kosaka K.
Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model.
Neuroreport. 2003 Mar 24;14(4):551-4.

Yamaguchi A, Katsuyama K, Suzuki K, Kosaka K, Aoki I, Yamanaka S.
Plasmid-based gene transfer ameliorates visceral storage in a mouse model of Sandhoff disease.
J Mol Med. 2003 Mar;81(3):185-93. Epub 2003 Feb 12.

Marui W, Iseki E, Kato M, Kosaka K.
Degeneration of tyrosine hydroxylase-immunoreactive neurons in the cerebral cortex and hippocampus of patients with dementia with Lewy bodies.
Neurosci Lett. 2003 Apr 17;340(3):185-8.

Tani S, Akatsu H, Ishikawa Y, Okada N, Okada H.
Preferential detection of pro-carboxypeptidase R by enzyme-linked immunosorbent assay.
Microbiol Immunol. 2003;47(4):295-300.

Horimoto Y, Matsumoto M, Akatsu H, Ikari H, Kojima K, Yamamoto T, Otsuka Y, Ojika K, Ueda R, Kosaka K.
Autonomic dysfunctions in dementia with Lewy bodies.
J Neurol. 2003 May;250(5):530-3.

Shibuya K, Uchihara T, Nakamura A, Ishiyama M, Yamaoka K, Yagishita S, Iwabuchi K, Kosaka K.
Reversible conformational change of tau2 epitope on exposure to detergent in glial cytoplasmic inclusions of multiple system atrophy.
Acta Neuropathol (Berl). 2003 May;105(5):508-14. Epub 2003 Feb 26.

Farkas I, Takahashi M, Fukuda A, Yamamoto N, Akatsu H, Baranyi L, Tateyama H, Yamamoto T, Okada N, Okada H.
Complement C5a Receptor-Mediated Signaling May Be Involved in Neurodegeneration in Alzheimer’s Disease
J Immunol. 2003 Jun 1;170(11):5764-71.

Odawara T, Shiozaki K, Iseki E, Hino H, Kosaka K.
Alterations of muscarinic acetylcholine receptors in atypical Pick's disease without Pick bodies.
J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):965-7.

Katsuse O, Iseki E, Marui W, Kosaka K.
Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies.
J Neurol Sci. 2003 Jul 15;211(1-2):29-35.

Kanai Y.
The role of non-chromosomal histones in the host defense system.
Microbiol Immunol. 2003;47(8):553-6.

Katsuse O, Iseki E, Arai T, Akiyama H, Togo T, Uchikado H, Kato M, de Silva R, Lees A, Kosaka K.
4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy.
Acta Neuropathol (Berl). 2003 Sep;106(3):251-60. Epub 2003 Jun 11.

Umegaki H, Ishiwata K, Ogawa O, Ingram DK, Roth GS, Oda K, Kurotani S, Kawamura K, Wang WF, Ikari H, Senda M, Iguchi A.
Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study.
Neuroscience. 2003;121(2):479-86.

Horimoto Y, Matsumoto M, Nakazawa H, Yuasa H, Morishita M, Akatsu H, Ikari H, Yamamoto T, Kosaka K.
Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson disease with dementia.
J Neurol Sci. 2003 Dec 15;216(1):105-8.

Kanai Y and Akatsu H.
Normal immune response to histone-related nuclear antigens in senile dementia such as Alzheimer's disease.
Proc Jap Soci Immunol 2003; 33: pp 202

Odawara T, Iseki E, Kanai A, Arai T, Katsuragi T, Hino H, Furukawa Y, Kato M, Yamamoto T, Kosaka K.
Clinicopathological study of two subtypes of Pick's disease in Japan.
Dement Geriatr Cogn Disord. 2003;15(1):19-25.

Francis K, Lewis BM, Akatsu H, Monk PN, Cain SA, Scanlon MF, Morgan BP, Ham J, Gasque P.
Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation.
FASEB J. 2003 Dec;17(15):2266-8. Epub 2003 Oct 16.

Takahashi E, Tateyama H, Akatsu H, Fukai I, Yamakawa Y, Fujii Y, Eimoto T.
Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors.
Hum Pathol. 2003 Dec;34(12):1253-8.

堤 玲子、相原道子、石和万美子、高橋一夫、大西秀樹、山田和夫、木村博和、小阪憲司、池澤善郎
アトピー性皮膚炎患者における適応障害(第1報)-精神医学的実態について-
日本皮膚科学会雑誌 2003;113:19-24

堤 玲子、相原道子、石和万美子、高橋一夫、大西秀樹、山田和夫、木村博和、小阪憲司、池澤善郎
アトピー性皮膚炎患者における適応障害(第2報)-2症例における介入の実際-
日本皮膚科学会雑誌 2003;113:25-30

小阪憲司
アルツハイマー病の診断基準
診断と治療 2003;91:231-235

都甲 崇、井関栄三、加瀬昭彦、内門大丈、勝瀬大海、小阪憲司
Olauzapineが奏効した躁病の1症例
精神医学 2003;45(2):183-186

松本俊彦、山口亜希子、上篠敦史、南堤一、遠藤桂子、矢花辰夫、岸本英 、小阪憲司
女性物質使用障害における摂取障害―乱用物質と摂取障害の関係について
精神医学 2003;45:119-127

丸井和美、井関栄三、中野光子、小阪憲司
塩酸ドネペジルにより頸部ジストニアとパーキソニズムの顕在化をみたパーキンソン病の1例
精神科治療学 2003;18:185-189

小田原俊成、小阪憲司
フルボキサミンがBPSDに有効であった痴呆症例をめぐって
分子精神医学 2003;3:83-84,

岡村信行、末元隆寛、工藤幸司、澤田 徹、荒井啓行、佐々木英忠、赤津裕康、山本孝之
ADの画像診断:生体における脳アミロイドイメージング技術の開発
遺伝子医学 23号 2003.3 Vol.7 No.1

丸井和美、井関栄三、杉山直也、松村雄彦、鈴木京子、小田原俊成、日野博昭、小阪憲司
プレセニリン1遺伝子異常を伴う家族性アルツハイマー病の1家系―家系内での発症年齢の若年化とApoE遺伝子多型について―
脳と神経 2003;55:349-353

蟹江治郎、赤津裕康、各務千鶴子
経腸栄養剤固形化によるPEG後期合併症への対策
臨床看護 2003;29(5):664-670

小阪憲司
私の恩師「猪瀬先生」
最新精神医学 2003;8(6);605

塩崎一昌、日野博昭、瀬川光子、角田卓治、小阪憲司
横浜市における痴呆性高齢者緊急一時入院制度により緊急入院を要した高齢者の特徴とその問題点
老年精神医学雑誌 2003;14:891-897

小阪憲司
新しい病気の発見
脳の科学 2003;25:1019-1022

TOPへ 

 
2004年

Suemoto T, Okamura N, Shiomitsu T, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Kudo Y, Sawada T
In vivo labeling of amyloid with BF-108.
Neurosci Res. 2004 Jan;48(1):65-74.

Okamura N, Suemoto T, Shimadzu H, Suzuki M, Shiomitsu T, Akatsu H, Yamamoto T, Staufenbiel M, Yanai K, Arai H, Sasaki H, Kudo Y, Sawada T
Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain.
J Neurosci. 2004 Mar 10;24(10):2535-41.

Kanie J, Suzuki Y, Iguchi A, Akatsu H, Yamamoto T, Shimokata H.
Prevention of gastroesophageal reflux using an application of half-solid nutrients in patients with percutaneous endoscopic gastrostomy feeding.
J Am Geriatr Soc. 2004 Mar;52(3):466-7.

Heese K, Yamada T, Akatsu H, Yamamoto T, Kosaka K, Nagai Y, Sawada T.
Characterizing the new transcription regulator protein p60TRP.
J Cell Biochem. 2004 Apr 1;91(5):1030-42.

Marui W, Iseki E, Kato M, Akatsu H, Kosaka K.
Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease.
Acta Neuropathol. 2004 Aug;108(2):121-8. Epub 2004 May 14.

Hiroyasu AKATSU, Kouzin KAMINO, Hidehisa YAMAGATA, Daisuke ISOJIMA, Ikuko KONDO, Takayuki YAMAMOTO, Tomoyuki KIDA, Masatoshi TAKEDA, Tetsuro MIKI, Kenji KOSAKA
Increased incidence of dementia with Lewy bodies in patients carrying the ɛ4-allele of apolipoprotein E
Psychogeriatrics Volume 4, Issue 2, pages 24–32, June 2004

Yamagata H, Chen Y, Akatsu H, Kamino K, Ito J, Yokoyama S, Yamamoto T, Kosaka K, Miki T, Kondo I.
Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease.
Biochem Biophys Res Commun. 2004 Aug 20;321(2):320-3.

Okamura N, Suemoto T, Shiomitsu T, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Arai H, Sasaki H, Yanai K, Staufenbiel M, Kudo Y, Sawada T.
A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain.
J Mol Neurosci. 2004;24(2):247-55.

Heese K, Fujita M, Akatsu H, Yamamoto T, Kosaka K, Nagai Y, Sawada T.
The Splicing Regulatory Protein p18SRP Is Down-Regulated in Alzheimer's Disease Brain.
J Mol Neurosci. 2004;24(2):269-76.

Akatsu H, Yamagata H, Chen Y, Miki T, Kamino K, Takeda M, Campbell W, Kondo I, Kosaka K, Yamamoto T, Okada H.
TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction.
Br J Haematol. 2004 Nov;127(4):440-7.

Kanie J, Suzuki Y, Akatsu H, Kuzuya M, Iguchi A.
Prevention of late complications by half-solid enteral nutrients in percutaneous endoscopic gastrostomy tube feeding.
Gerontology. 2004 Nov-Dec;50(6):417-9.

蟹江治郎、鈴木祐介、赤津裕康、各務千鶴子
固形化経腸栄養剤の実施における栄養剤の安定性と安全性の評価-調理によるビタミンの変化と細菌学的変化-
静脈経腸栄養 19(1):65-69 2004
TOPへ 

 
2005年

Taguchi K, Yamagata H, Zhong W, Kamino K, Akatsu H, Hata R, Yamamoto T, Kosaka K, Takeda M, Kondo I, Miki T
Identification of hippocampus-related candidate genes for Alzheimer's disease.
Ann Neurol. 2005 Apr;57(4):585-8.

Zhong W, Yamagata HD, Taguchi K, Akatsu H, Kamino K, Yamamoto T, Kosaka K, Takeda M, Kondo I, Miki T.
Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease.
J Neurol Sci. 2005 Nov 15;238(1-2):53-7. Epub 2005 Aug 16.

Satoh K, Hata M, Shimizu T, Yokota H, Akatsu H, Yamamoto T, Kosaka K, Yamada T.
Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix.
Biochem Biophys Res Commun. 2005 Sep 23;335(2):631-6.

Okamura N, Suemoto T, Furumoto S, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Fujiwara H, Nemoto M, Maruyama M, Arai H, Yanai K, Sawada T, Kudo Y.
Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.
J Neurosci. 2005 Nov 23;25(47):10857-62.

赤津裕康, 山本孝之, 鈴木裕介, 蟹江治郎
固形化経腸栄養剤の投与により血糖管理が容易になった1例
日本老年医学会雑誌 42(5), 564-566, 2005-09-25

蟹江治郎, 赤津裕康, 鈴木裕介
胃瘻チューブ交換時に生じた腹腔内誤挿入に対し外来処置のみで対処が可能であった1例
日本老年医学会雑誌 42(6), 698-701, 2005-11-25

Yamamoto R, Iseki E, Marui W, Togo T, Katsuse O, Kato M, Isojima D, Akatsu H, Kosaka K, Arai H.
Non-uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies.
Neuropathology. 2005 Sep;25(3):188-94.

Togo T, Isojima D, Akatsu H, Suzuki K, Uchikado H, Katsuse O, Iseki E, Kosaka K, Hirayasu Y.
Clinical features of argyrophilic grain disease: a retrospective survey of cases with neuropsychiatric symptoms.
Am J Geriatr Psychiatry. 2005 Dec;13(12):1083-91.

TOPへ 

 
2006年

Fujishiro H, Umegaki H, Isojima D, Akatsu H, Iguchi A, Kosaka K.
Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies.
Acta Neuropathol (Berl). 2006 Feb;111(2):109-14. Epub 2006 Jan 19.

Clewing JM, Antalfy BC, Lucke T, Najafian B, Marwedel KM, Hori A, Powel RM, Safo Do AF, Najera L, SantaCruz K, Hicks MJ, Armstrong DL, Boerkoel CF.
Schimke immuno-osseous dysplasia: a clinicopathological correlation.
J Med Genet. 2007 Feb;44(2):122-30. Epub 2006 Jul 13.

Kimura R, Kamino K, Yamamoto M, Kida T, Akatsu H, Uema T, Kobayashi T, Hattori H, Nuripa A, Nessa BN, Kazui H, Ikejiri Y, Tanaka T, Tanii H, Kudo T, Yoneda H, Yamagata H, Miki T, Takeda M.
Albumin gene encoding free fatty acid and beta-amyloid transporter is genetically associated with Alzheimer disease.
Psychiatry Clin Neurosci. 2006 Apr;60 Suppl 1:S34-9.

Dammann O, Hori A, Szentiks C, Hewicker-Trautwein M.
Absence of pestivirus antigen in brains with white matter damage.
Dev Med Child Neurol. 2006 Apr;48(4):290-3.

Heese K, Akatsu H.
Alzheimer's disease--an interactive perspective.
Curr Alzheimer Res. 2006 Apr;3(2):109-21.

Waragai M, Wei J, Fujita M, Nakai M, Ho GJ, Masliah E, Akatsu H, Yamada T, Hashimoto M.
Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease.
Biochem Biophys Res Commun. 2006 Jul 7;345(3):967-72. Epub 2006 May 11.

Wollmer, M.A., Kapaki, E., Hersberger, M., Muntwyler, J., Brunner, F., Tsolaki, M., Akatsu, H., Kosaka, K., Michikawa, M., Molyva, D., Paraskevas, G.P., Lutjohann, D., von Eckardstein, A., Hock, C., Nitsch, R.M., Papassotiropoulos, A.
Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease.
Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141(5):534-6.

Satoh K, Hata M, Takahara S, Tsuzaki H, Yokota H, Akatsu H, Yamamoto T, Kosaka K, Yamada T.
A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes.
Brain Res. 2006 Jul 17

Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K.
Variations in the BDNF Gene in Autopsy-Confirmed Alzheimer's Disease and Dementia with Lewy Bodies in Japan
Dement Geriatr Cogn Disord. 2006;22(3):216-22. Epub 2006 Aug 7.

Isojima D, Togo T, Kosaka K, Fujishiro H, Akatsu H, Katsuse O, Iritani S, Matsumoto T, Hirayasu Y.
Vascular complications in dementia with Lewy bodies: a postmortem study
Neuropathology. 2006 Aug;26(4):293-7.

Petri S, Kollewe K, Grothe C, Hori A, Dengler R, Bufler J, Krampfl K.
GABA(A)-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients.
J Neurol Sci. 2006 Dec 1;250(1-2):124-32. Epub 2006 Oct 2.

Mitsuda N, Yamagata HD, Zhong W, Aoto M, Akatsu H, Uekawa N, Kamino K, Taguchi K, Yamamoto T, Maruyama M, Kosaka K, Takeda M, Kondo I, Miki T.
A novel alternative splice variant of nicastrin and its implication in Alzheimer disease.
Life Sci. 2006 Apr 18;78(21):2444-8. Epub 2005 Nov 21.

Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M.
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between {beta}-amyloid production and tau phosphorylation in Alzheimer disease.
Hum Mol Genet. 2006 Nov 29

Yokota T, Mishra M, Akatsu H, Tani Y, Miyauchi T, Yamamoto T, Kosaka K, Nagai Y, Sawada T, Heese K.
Brain site-specific gene expression analysis in Alzheimer's disease patients.
Eur J Clin Invest. 2006 Nov;36(11):820-30.

Hori A.
Causes of neuronal heterotopia other than migration disturbances.
Neuropathology. 2006 Dec;26(6):540-3.

Hori A.
Kapitel 4. Entwicklung des Zentralnervensystems.
In: Biedermann H (Hrsg) Manuelle Therapie bei Kindern. Indikation und Konzepte. Elsevier/Urban & Fischer, Munchen・Jena, March 2006 S.27-40

ten Donkelaar HJ, Mullaart RA, Hori A, Shiota K.
Chapter 4. Neurulation and neural tube defects.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical Neuroembryology: Development and developmental disorders of the human central nervous system.
Springer, Heidelberg-Berlin,Wien, New York-Tokyo, 2006, pp145-190

ten Donkelaar HJ, Hori A.
Chapter 6. Development and developmental disorders of the spinal cord.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical euroembryology: Development and developmental disorders of the human central nervous system.
Springer, Heidelberg-Berlin,Wien, New York-Tokyo, 2006, pp229-268

ten Donkelaar HJ, Lammens M, Wesseling P, Hori A.
Chapter 8. Development and developmental disorders of the human cerebellum.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical Neuroembryology: Development and developmental disorders of the human central nervous system.
Springer, Heidelberg-Berlin,Wien, New York-Tokyo, 2006, pp309-344

ten Donkelaar HJ, Lammens M, Cruysberg JRM, Hori A, Shiota K.
Chapter 9. Development and developmental disorders of the forebrain.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical Neuroembryology: Development and developmental disorders of the human central nervous system.
Springer, Heidelberg-Berlin,Wien, New York-Tokyo, 2006, pp345-428

ten Donkelaar HJ, Lammens M, Renier W, Hori A.
Chapter 10. Development and developmental disorders of the cerebral cortex.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical Neuroembryology: Development and developmental disorders of the human central nervous system.
Springer, Heidelberg-Berlin,Wien, New York-Tokyo, 2006. pp429-518

赤津裕康
αシヌクレインと認知症(痴呆)
老年期認知症ナビゲーター メディカルレビュー社 292-293, 2006
TOPへ 

 
2007年

Watanabe-Kaneko K, Sonoda T, Miyagi Y, Yamashita T, Okuda K, Kawamoto S.
The synaptic scaffolding protein Delphilin interacts with monocarboxylate transporter 2.
Neuroreport. 2007 Mar 26;18(5):489-93.

Kojima Y, Jounai N, Takeshita F, Nakazawa M, Okuda K, Watabe S, Xin KQ, Okuda K.
The degree of apoptosis as an immunostimulant for a DNA vaccine against HIV-1 infection.
Vaccine. 2007 Jan 5;25(3):438-45. Epub 2006 Aug 18.

Matsui K, Saha S, Saitoh M, Mizuki N, Itoh N, Okada E, Yoshida A, Xin KQ, Nishio O, Okuda K.
Isolation and identification of adenovirus from conjunctival scrapings over a two-year period (between 2001 and 2003) in Yokohama, Japan.
J Med Virol. 2007 Feb;79(2):200-5.

Takeshita F, Takase K, Tozuka M, Saha S, Okuda K, Ishii N, Sasaki S.
Muscle creatine kinase/SV40 hybrid promoter for muscle-targeted long-term transgene expression.
Int J Mol Med. 2007 Feb;19(2):309-15.

Xin KQ, Sekimoto Y, Takahashi T, Mizuguchi H, Ichino M, Yoshida A, Okuda K.
Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV.
Vaccine. 2007 May 10;25(19):3809-15. Epub 2007 Feb 20.

Saha S, Takeshita F, Matsuda T, Jounai N, Kobiyama K, Matsumoto T, Sasaki S, Yoshida A, Xin KQ, Klinman DM, Uematsu S, Ishii KJ, Akira S, Okuda K.
Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.
J Immunol. 2007 Jul 15;179(2):1147-54.

Someya K, Xin KQ, Ami Y, Izumi Y, Mizuguchi H, Ohta S, Yamamoto N, Honda M, Okuda K.
Chimeric adenovirus type 5/35 vector encoding SIV gag and HIV env genes affords protective immunity against the simian/human immunodeficiency virus in monkeys.
Virology. 2007 Oct 25;367(2):390-7. Epub 2007 Jul 12.

Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki K, Okuda K.
The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14050-5. Epub 2007 Aug 20.

Ohba K, Yoshida S, Zahidunnabi Dewan M, Shimura H, Sakamaki N, Takeshita F, Yamamoto N, Okuda K.
Mutant influenza A virus nucleoprotein is preferentially localized in the cytoplasm and its immunization in mice shows higher immunogenicity and cross-reactivity.
Vaccine. 2007 May 22;25(21):4291-300. Epub 2007 Mar 12.

Shigematsu T, Suda N, Okuda K, Fukushima J.
Reliable enzyme-linked immunosorbent assay systems for pathogenic factors of Pseudomonas aeruginosa alkaline proteinase, elastase, and exotoxin A: a comparison of methods for labeling detection antibodies with horseradish peroxidase.
Microbiol Immunol. 2007;51(12):1149-59.

Makino S, Kaji R, Ando S, Tomizawa M, Yasuno K, Goto S, Matsumoto S, Tabuena MD, Maranon E, Dantes M, Lee LV, Ogasawara K, Tooyama I, Akatsu H, Nishimura M, Tamiya G.
Reduced Neuron-Specific Expression of the TAF1 Gene Is Associated with X-Linked Dystonia-Parkinsonism.
Am J Hum Genet. 2007 Mar;80(3):393-406. Epub 2007 Jan 23.

Akatsu H, Ishiguro M, Ogawa N, Kanesaka T, Okada N, Yamamoto T, Campbell W, Okada H.
Plasma Levels of Unactivated Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Are Down-Regulated in Young Adult Women: Analysis of a Normal Japanese Population.
Microbiol Immunol. 2007;51(5):507-17.

Rittierodt M, Hori A.
Pre-morbid morphological conditions of the human pituitary.
Neuropathology. 2007 Feb;27(1):43-8.

小西吉裕、堀 映
欧米におけるリサーチリソース確保(とくにブレインバンク)と運用の実状 ―わが国でのそれの効率的運用の為に―
神経・筋疾患と慢性精神疾患等のリサーチ・リソース(剖検脳の組織)の確保とそのシステム整備に関する研究(16指―4)
総括研究実績報告書(平成16―18年度)116-118, March 2007

赤津裕康、松本光弘、宮本圭子、山本淑子、芦田欣也、高見正雄、小橋修
胃瘻患者への短期間のたんぱく質強化による栄養介入効果とインフルエンザワクチン抗体価に及ぼす影響
栄養評価と治療 24(3) 307-314, 2007

Nakai M, Fujita M, Waragai M, Sugama S, Wei J, Akatsu H, Ohtaka-Maruyama C, Okado H, Hashimoto M.
Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage.
Biochem Biophys Res Commun. 2007 Jun 22;358(1):104-10. Epub 2007 Apr 25.

Wei J, Fujita M, Nakai M, Waragai M, Watabe K, Akatsu H, Rockenstein E, Masliah E, Hashimoto M.
Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies.
J Biol Chem. 2007 Sep 28;282(39):28904-14. Epub 2007 Jul 24.

Waragai M, Nakai M, Wei J, Fujita M, Mizuno H, Ho G, Masliah E, Akatsu H, Yokochi F, Hashimoto M.
Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease.
Neurosci Lett. 2007 Sep 20;425(1):18-22. Epub 2007 Aug 11.

Zou K, Yamaguchi H, Akatsu H, Sakamoto T, Ko M, Mizoguchi K, Gong JS, Yu W, Yamamoto T, Kosaka K, Yanagisawa K, Michikawa M.
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition.
J Neurosci. 2007 Aug 8;27(32):8628-35.

Kanai Y, Akatsu H, Iizuka H, Morimoto C.
Could serum antibody to poly(ADP-ribose) and/or histone H1 be marker for senile dementia of Alzheimer type?
Ann N Y Acad Sci. 2007 Aug;1109:338-44.

堀 映
脳の発達:正常と異常(特集 実地病理医に必要な神経病理II 変性・炎症・小児)
病理と臨床 25(11):1139-1147 2007

Clewing JM, Antalfy BC, Lu"cke T, Najafian B, Marwedel KM, Hori A, Powel RM, Do AF, Najera L, SantaCruz K, Hicks MJ, Armstrong DL, Boerkoel CF.
Schimke immuno-osseous dysplasia: a clinicopathological correlation.
J Med Genet. 2007 Feb;44(2):122-30. Epub 2006 Jul 13.

Okamura N, Furumoto S, Funaki Y, Suemoto T, Kato M, Ishikawa Y, Ito S, Akatsu H, Yamamoto T, Sawada T, Arai H, Kudo Y and Yanai K.
Binding and safety profile of novel benzoxazole derivative for in vivo imaging of amyloid deposits in Alzheimer's disease
Geriatrics & Gerontology International. Volume 7 Issue 4 Page 393-400, December 2007

Hiroshige FUJISHIRO, Hiroyuki UMEGAKI, Yusuke SUZUKI, Daisuke ISOJIMA, Hiroyasu AKATSU, Hiroyuki IKARI, Akihisa IGUCHI and Kenji KOSAKA
Clinical profiles of autopsy-confirmed dementia with Lewy bodies at institutionalization: Comparison with Alzheimer’s disease
Psychogeriatrics Volume 7 Issue 3 Page 98-103, September 2007

Nozaki I, Watanabe T, Kawaguchi M, Akatsu H, Tsuneyama K, Yamamoto Y, Ohe K, Yonekura H, Yamada M, Yamamoto H.
Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains.
Arch Histol Cytol. 2007 Dec;70(5):279-90.


TOPへ 

 
2008年

Shirotake S, Tomita Y, Yoshizaki S, Okuda K.
Preparation of cyanoacrylate nanoparticles using monosaccharides or disaccharides.
Chem Pharm Bull (Tokyo). 2008 Jan;56(1):137-8.

Takeshita F, Kobiyama K, Miyawaki A, Jounai N, Okuda K.
The non-canonical role of Atg family members as suppressors of innate antiviral immune signaling.
Autophagy. 2008 Jan 1;4(1):67-9. Epub 2007 Sep 10.

Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda J, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M.
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.
J Hum Genet. 2008;53(4):296-302. Epub 2008 Jan 31

堀 映
乳幼児虐待の背景にある要因について―12例の解析―
鳥取臨床科学研究会誌 1(1): 95-100 2008

Komatsu F, Farkas I, Akatsu H, Kojima K, Fukushima T, Okada H.
Potential neural progenitor cells in fetal liver and regenerating liver.
Cytotechnology. 2008 Mar;56(3):209-17. Epub 2008 Jun 5.

Matsui K, Shimizu H, Yoshida A, Nagaoka E, Nishio O, Okuda K.
Monitoring of adenovirus from conjunctival scrapings in Japan during 2005--2006.
J Med Virol. 2008 Jun;80(6):997-1003.

Taniguchi M, Okayama Y, Hashimoto Y, Kitaura M, Jimbo D, Wakutani Y, Wada-Isoe K, Nakashima K, Akatsu H, Furukawa K, Arai H, Urakami K.
Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease.
Dement Geriatr Cogn Disord. 2008;26(2):117-22. Epub 2008 Jul 24.

Liu Y, Mimuro M, Yoshida M, Hashizume Y, Niwa H, Miyao S, Ujihira N, Akatsu H.
Inclusion-positive cell types in adult-onset intranuclear inclusion body disease: implications for clinical diagnosis.
Acta Neuropathol. 2008 Dec;116(6):615-23. Epub 2008 Oct 16.

赤津裕康、宮本圭子、山本淑子、堀映、小橋修、小阪憲司、山本孝之
福祉村病院における栄養サポートチーム(NST)の介入が及ぼした影響について
鳥取臨床科学研究会雑誌1(1), 47-53 (2008)

TOPへ 

 
2009年

Kobiyama K, Takeshita F, Ishii KJ, Koyama S, Aoshi T, Akira S, Sakaue-Sawano A, Miyawaki A, Yamanaka Y, Hirano H, Suzuki K, Okuda K.
A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant.
J Immunol. 2009 Feb 1;182(3)

Ura T, Yoshida A, Xin KQ, Yoshizaki S, Yashima S, Abe S, Mizuguchi H, Okuda K.
Designed recombinant adenovirus type 5 vector induced envelope-specific CD8(+) cytotoxic T lymphocytes and cross-reactive neutralizing antibodies against human immunodeficiency virus type 1.
J Gene Med. 2009 Feb;11(2):139-49.

Shimada M, Wang HB, Kondo A, Xu XP, Yoshida A, Shinoda K, Ura T, Mizuguchi H, Klinman D, Luo JL, Bai H, Okuda K.
Effect of therapeutic immunization using Ad5/35 and MVA vectors on SIV infection of rhesus monkeys undergoing antiretroviral therapy.
Gene Ther. 2009 Feb;16(2):218-28. Epub 2008 Oct 16.

石黒雅江
LAK-T療法の向神経作用
Biotherapy 23(1):21-27,January,2009

赤津裕康、伊苅弘之、松山善次郎、小橋修、瀬藤光利、山本孝之
高カロリー輸液にて栄養管理している高齢者における栄養・微量元素の推移に関する研究
新薬と臨床 第58巻第11号別冊 2009.11.10

Okita K, Matsukawa N, Maki M, Nakazawa H, Katada E, Hattori M, Akatsu H, Borlongan CV, Ojika K.
Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease.
Biochem Biophys Res Commun. 2009 Feb 6;379(2):272-6.

Kimura R, Yamamoto M, Morihara T, Akatsu H, Kudo T, Kamino K, Takeda M.
SORL1 is genetically associated with Alzheimer disease in a Japanese population.
Neurosci Lett. 2009 Sep 18;461(2):177-80. Epub 2009 Jun 17.

Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T.
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
J Biol Chem. 2009 Dec 25;284(52):36024-33.

堀 映
脊髄発育異常の病理学: 1. 神経管形成異常
脊椎脊髄ジャーナル 22(6) 727-732 2009

堀 映
脊髄発育異常の病理学: 2. 終室と終室嚢胞および仙尾部皮下上衣腫
脊椎脊髄ジャーナル 22(7) 817-820 2009

堀 映
脊髄発育異常の病理学: 3. 終糸と脊髄係留症候群、および脊髄の発育と加齢
脊椎脊髄ジャーナル 22(8) 905-911 2009

堀 映
脊髄発育異常の病理学: 4. 人尾と偽尾
脊椎脊髄ジャーナル 22(9) 999-1001 2009

堀 映,赤津 裕康
脊髄発育異常の病理学: 5. 脊髄神経根の走行異常
脊椎脊髄ジャーナル 22(10) 1095-1101 2009

堀 映
脊髄発育異常の病理学: 6. 脊髄神経路(索)の走行異常ならびに脊髄の縦溝について
脊椎脊髄ジャーナル 22(11) 1189-1196 2009

堀 映
脊髄発育異常の病理学: 7. 仙部無形成
脊椎脊髄ジャーナル 22(12) 1265-1268 2009


TOPへ 

 
2010年

Fukumoto N, Fujii T, Combarros O, Kamboh MI, Tsai SJ, Matsushita S, Nacmias B, Comings DE, Arboleda H, Ingelsson M, Hyman BT, Akatsu H, Grupe A, Nishimura AL, Zatz M, Mattila KM, Rinne J, Goto Y, Asada T, Nakamura S, Kunugi H.
Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis.
Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):235-42.

Mimuro M, Yoshida M, Miyao S, Harada T, Ishiguro K, Hashizume Y.
Neuronal and glial tau pathology in early frontotemporal lobar degeneration-tau, Pick's disease subtype.
J Neurol Sci. 2010 Mar 15;290(1-2):177-82

Yashima S, Yoshizaki S, Shinoda K, Yoshida A, Kondo A, Mizuguchi H, Ryo A, Okuda K, Shimada M.
Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells.
Vaccine. 2010 Apr 19;28(18):3257-64.

Murayama A, Weng L, Date T, Akazawa D, Tian X, Suzuki T, Kato T, Tanaka Y, Mizokami M, Wakita T, Toyoda T.
RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells.
PLoS Pathog. 2010 Apr 29;6(4)

Wang HB, Kondo A, Yoshida A, Yoshizaki S, Abe S, Bao LL, Mizuki N, Ichino M, Klinman D, Okuda K, Shimada M.
Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys.
Gene Ther. 2010 Jan;17(1):4-13.

Bernasconi R, Galli C, Calanca V, Nakajima T, Molinari M.
Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates.
J Cell Biol. 2010 Jan 25;188(2):223-35.

堀 映
脊髄発育異常の病理学: 8 脊髄神経根内の異所性神経細胞と脊髄内異所性灰白質
脊椎脊髄ジャーナル 23(1) 7-13 2010

堀 映
脊髄発育異常の病理学: 9 脊髄正中離開
脊椎脊髄ジャーナル 23(2) 89-93 2010

堀 映
松村 明: 脊髄発育異常の病理学: 10 部分重複脊髄
脊椎脊髄ジャーナル 23(3) 165-171 2010

堀 映
脊髄発育異常の病理学: 11 重合体の重複脊髄と単体脊髄における脊髄半側低形成
脊椎脊髄ジャーナル 23(5) 487-491 2010

Zhang S, Weng L, Geng L, Wang J, Zhou J, Deubel V, Buchy P, Toyoda T.
Biochemical and kinetic analysis of the influenza virus RNA polymerase purified from insect cells.
Biochem Biophys Res Commun. 2010 Jan 1;391(1):570-4. Epub 2009 Nov 20.

Akatsu H.
Collaboration between Fukushimura Brain Bank,based in a private geriatric hospital and a national/international network
Brain Nerve. 2010 Oct;62(10):1043-52.

Weng L, Hirata Y, Arai M, Kohara M, Wakita T, Watashi K, Shimotohno K, He Y, Zhong J, Toyoda T.
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner.
J Virol. 2010 Nov;84(22):11761-70.

Zhang S, Wang J, Wang Q, Toyoda T.
Internal initiation of influenza virus replication of viral RNA and complementary RNA in vitro.
J Biol Chem. 2010 Dec 24;285(52):41194-201.

Jiang H, Zhang S, Wang Q, Wang J, Geng L, Toyoda T.
Influenza virus genome C4 promoter/origin attenuates its transcription and replication activity by the low polymerase recognition activity.
Virology. 2010 Dec 20;408(2):190-6. Epub

Leiyun Weng, Qiang Wang, Wei Wang, Peijun Ren, Vincent Deubel, Tetsuya Toyoda.
Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration
Influenza Research and Treatment, Volume 2010 (2010), Article ID 976084, 3 pages

Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung CG, Komano H, Michikawa M.
Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function.
J Biol Chem. 2010 Dec 3;285(49):38382-8. Epub 2010 Oct 1.

赤津 裕康
療養型病床群を基盤とする福祉村ブレインバンクと内外連携
BRAIN and NERVE-神経研究の進歩 Vol.62 No.10;1043-1052, 2010

TOPへ 

 
2011年

橋詰 良夫
血管内リンパ腫の病理 (特集 神経系と血管内リンパ腫)
脳と神経2011、63:459-466

Akatsu H, Ogawa N, Kanesaka T, Hori A, Yamamoto T, Matsukawa N, Michikawa M.
Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease.
J Neurol Sci. 2011 Jan 15;300(1-2):67-73. Epub 2010 Nov 1.

Hashizume M, Takagi J, Kanehira T, Otake K, Mimuro M, Yoshida M, Hashizume Y.
Histologic study of age-related change in the posterior pituitary gland focusing on abnormal deposition of tau protein.
Pathol Int. 2011 Jan;61(1):13-8.

Zhang S, Wang Q, Wang J, Mizumoto K, Toyoda T.
Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity.
Biochim Biophys Acta. 2012 Jan;1819(1):78-83.

Jiang H, Weng L, Zhang N, Arita M, Li R, Chen L, Toyoda T.
Biochemical characterization of enterovirus 71 3D RNA polymerase.


Zhong C, Li C, Wang X, Toyoda T, Gao G, Fan Z.
Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells.
Cell Death Differ. 2012 May;19(5):882-90.

Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Leverenz J, Fagan A, Goate A, Bateman R, Holtzman DM, Yamamoto T, Nakaya T, Gandy S, Suzuki T.
Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and alzheimer's disease: Evidence for γ-secretase dysfunction.
Ann Neurol. 2011 Jun;69(6):1026-31

Ibrahim MS, Watanabe Y, Ellakany HF, Yamagishi A, Sapsutthipas S, Toyoda T, Abd El-Hamied HS, Ikuta K.
Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1).
Virus Genes. 2011 Jun;42(3):363-8. Epub 2011 Feb 17.

Matsumoto J, Sugiura Y, Yuki D, Hayasaka T, Goto-Inoue N, Zaima N, Kunii Y, Wada A, Yang Q, Nishiura K, Akatsu H, Hori A, Hashizume Y, Yamamoto T, Ikemoto K, Setou M, Niwa S.
Abnormal phospholipids distribution in the prefrontal cortex from a patient with schizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry.
Anal Bioanal Chem. 2011 Jun;400(7):1933-43. Epub 2011 Apr 2.

Shijian Zhang and Tetsuya Toyoda.
Molecular mechanisms of transcription and replication of the influenza virus genome.
Frontier in Biology 6: 446-461, 2011.

Yuki D, Sugiura Y, Zaima N, Akatsu H, Hashizume Y, Yamamoto T, Fujiwara M, Sugiyama K, Setou M.
Hydroxylated and non-hydroxylated sulfatide are distinctly distributed in the human cerebral cortex.
Neuroscience. 2011 Oct 13;193:44-53. Epub 2011 Jul 28.

Iwasaki Y, Mimuro M, Yoshida M, Kitamoto T, Hashizume Y.
Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians.
Eur J Neurol. 2011 Jul;18(7):999-1002.

Wang Y, Wang Y, Xu Y, Tong W, Pan T, Li J, Sun S, Shao J, Ding H, Toyoda T, Yuan Z.
Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).
J Biol Chem. 2011 Jul 29;286(30):26603-15.

Mishra M, Akatsu H, Heese K.
The novel protein MANI modulates neurogenesis and neurite-cone growth.
J Cell Mol Med. 2011 Aug;15(8):1713-25.

Imagama S, Ito Z, Wakao N, Sakai Y, Kato F, Yukawa Y, Sato K, Ando K, Hirano K, Tauchi R, Muramoto A, Hashizume Y, Matsuyama Y, Ishiguro N.
Differentiation of localization of spinal hemangioblastomas based on imaging and pathological findings.
Eur Spine J. 2011 Aug;20(8):1377-84.

ten Donkelaar HJ, Hori A:
Chapter 11 Basal ganglia. In: ten Donkelaar HJ: Clinical Neuroanatomy.Brain Circuitry and Its Disorders.
Springer-Verlag Berlin Heidelberg 2011 pp495-564 (DOI:10.1007/978-3-642-19134-3)

ten Donkelaar HJ, Hori A:
Chapter 13 The hypothalamus and hypothalamohypophysial systems. In: ten Donkelaar HJ: Clinical Neuroanatomy. Brain Circuitry and Its Disorders.
Springer-Verlag Berlin Heidelberg 2011 pp603-631 (DOI:10.1007/978-3-642-19134-3)

ten Donkelaar HJ, Hori A:
Chapter 14 The lymbic system. In: ten Donkelaar HJ: Clinical Neuroanatomy. Brain Circuitry and Its Disorders.
Springer-Verlag Berlin Heidelberg 2011 pp633-710 (DOI:10.1007/978-3-642-19134-3)

ten Donkelaar HJ, van Domburg P, Eling P, Keyser A, Kusters B, Hori A:
Chapter 15 The cerebral cortex and complex cerebral functions. In: ten Donkelaar HJ: Clinical Neuroanatomy. Brain Circuitry and Its Disorders.
Springer-Verlag Berlin Heidelberg 2011 pp711-809 (DOI:10.1007/978-3-642-19134-3)

赤津裕康
高齢者における胃瘻管理
臨床栄養 vol.118, No.6, 2011.5, 658-669

赤津裕康、瀬藤光利、山本孝之
高齢者における完全静脈栄養管理時のビタミンの検討
静脈経腸栄養 vol.26, No.3, 2011, 977-982

Wohlsein P, Baumgartner W, Kreipe HH, Haverich A, Hori A, Stan AC.
Rabies transmission through organ transplantation
Pathologe. 2011 Sep;32(5):406-10.

Horimoto Y, Matsumoto M, Akatsu H, Kojima A, Yoshida M, Nokura K, Yuasa H, Katada E, Yamamoto T, Kosaka K, Hashizume Y, Yamamoto H, Mitake S.
Longitudinal study on MRI intensity changes of Machado-Joseph disease: correlation between MRI findings and neuropathological changes.
J Neurol. 2011 Sep;258(9):1657-64.

Mizukami K, Ishikawa M, Akatsu H, Abrahamson EE, Ikonomovic MD, Asada T.
An immunohistochemical study of the serotonin 1A receptor in the hippocampus of subjects with Alzheimer's disease.
Neuropathology. 2011 Oct;31(5):503-9.

Saito Y, Iwasaki Y, Aiba I, Kitamoto T, Yoshida M, Hashizume Y.
An autopsy case of MM2-cortical + thalamic-type sporadic Creutzfeldt-Jakob disease.
Neuropathology. 2011 Oct;31(5):523-30.

Iwasaki Y, Mori K, Ito M, Nagaoka M, Ieda T, Kitamoto T, Yoshida M, Hashizume Y.
An autopsied case of V180I Creutzfeldt-Jakob disease presenting with panencephalopathic-type pathology and a characteristic prion protein type.
Neuropathology. 2011 Oct;31(5):540-8.

Tanei T, Nakahara N, Takebayashi S, Ito M, Hashizume Y, Wakabayashi T.
Primary angiitis of the central nervous system mimicking tumor-like lesion--case report.
Neurol Med Chir (Tokyo). 2011;51(1):56-9.

Konno T, Hata S, Hamada Y, Horikoshi-Sakuraba Y, Nakaya T, Saito Y, Yamamoto T, Yamamoto T, Maeda M, Ikeuchi T, Gandy S, Akatsu H, Suzuki T, Neuroimaging Initiative TJ.
Coordinated increase of [gamma]-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients : Quantitative analysis of p3-Alc[alpha] with a new ELISA system.
Mol Neurodegener. 2011 Nov 8;6(1):76.


Immunohistochemical expression of fibroblast growth factor-2 in developing human cerebrum and epilepsy-associated malformations of cortical development.


Hishikawa N, Niwa H, Hara T, Hara K, Ito M, Shimada S, Yoshida M, Hashizume Y, Murakami N.
An autopsy case of lymphomatosis cerebri showing pathological changes of intravascular large B-cell lymphoma in visceral organs.
Neuropathology. 2011 Dec;31(6):612-9.

Fujita K, Yoshida M, Sako W, Maeda K, Hashizume Y, Goto S, Sobue G, Izumi Y, Kaji R.
Brainstem and spinal cord motor neuron involvement with optineurin inclusions in proximal-dominant hereditary motor and sensory neuropathy.
J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1402-3.


TOPへ 

 
2012年

Tamura T, Yoshida M, Hashizume Y, Sobue G.
Lewy body-related α-synucleinopathy in the spinal cord of cases with incidental Lewy body disease.
Neuropathology. 2012 Feb;32(1):13-22.

Satoh K, Akatsu H, Yamamoto T, Kosaka K, Yokota H, Yamada T.
Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes.
Brain Res. 2012 Mar 2;1441:9-16. Epub 2012 Jan 12.

橋詰 良夫
高齢者の脊椎脊髄疾患の病理
Journal of spine research : 2012,3:176-181

蟹江治郎、赤津裕康
半固形栄養材の物性による注入後カテーテル内残留量の比較
静脈経腸栄養vol 27, No3, 2012, p59-64

Akatsu H, Hori A, Yamamoto T, Yoshida M, Mimuro M, Hashizume Y, Tooyama I, Yezdimer EM.
Transition metal abnormalities in progressive dementias.
Biometals. 2012 Apr;25(2):337-50. Epub 2011 Nov 12.

Weng L, Kohara M, Wakita T, Shimotohno K, Toyoda T.
Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase.
Gene. 2012 Apr 1;496(2):79-87.

Wang Q, Weng L, Tian X, Counor D, Sun J, Mao Y, Deubel V, Okada H, Toyoda T.
Effect of the methyltransferase domain of Japanese encephalitis virus NS5 on the polymerase activity.
Biochim Biophys Acta. 2012 May;1819(5):411-8.

Hosono-Fukao T, Ohtake-Niimi S, Hoshino H, Britschgi M, Akatsu H, Hossain MM, Nishitsuji K, van Kuppevelt TH, Kimata K, Michikawa M, Wyss-Coray T, Uchimura K.
Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid s plaques of Alzheimer's disease: evidence from mouse models and patients.
Am J Pathol. 2012 May;180(5):2056-67. Epub 2012 Mar 17.

Akira Hori
Normale und pathologische Entwicklung des Nervensystems
PATHOLOGIE 2012, I, 43-85, DOI: 10.1007/978-3-642-02324-8_3

Qiang Wang, Shijian Zhang, Hongbing Jiang, Jinalan Wang, Leiyun Weng, Yingying Mao, Satoshi Sekiguchi, Fumihiko Yasui, Michinori Kohara, Philippe Buchy, Vincent Deubel, Ke Xu, Bing Sun and Tetsuya Toyoda
PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection
Virology Journal 2012, 9:106

Sorn S, Sok T, Ly S, Rith S, Tung N, Viari A, Gavotte L, Holl D, Seng H, Asgari N, Richner B, Laurent D, Chea N, Duong V, Toyoda T, Yasuda CY, Kitsutani P, Zhou P, Bing S, Deubel V, Donis R, Frutos R, Buchy P.
Dynamic of H5N1 virus in Cambodia and emergence of a novel endemic sub-clade.
Infect Genet Evol. 2012 Jun 6.

Sorn S, Sok T, Ly S, Rith S, Tung N, Viari A, Gavotte L, Holl D, Seng H, Asgari N, Richner B, Laurent D, Chea N, Duong V, Toyoda T, Yasuda CY, Kitsutani P, Zhou P, Bing S, Deubel V, Donis R, Frutos R, Buchy P.
Dynamic of H5N1 virus in Cambodia and emergence of a novel endemic sub-clade.
Infect Genet Evol. 2012 Jun 7.

Hirayama M, Nosaki Y, Matsui K, Terao S, Kuwayama M, Tateyama H, Yoshida M, Hashizume Y.
Efficacy of mefloquine to progressive multifocal leukoencephalopathy initially presented with parkinsonism.
Clin Neurol Neurosurg. 2012 Jul;114(6):728-31.

Yuichi Hirata, Kazutaka Ikeda, Masayuki Sudoh, Yuko Tokunaga, Akemi Suzuki, Leiyun Weng, Masatoshi Ohta, Yoshimi Tobita, Ken Okano, Kazuhisa Ozeki, Kenichi Kawasaki, Takuo Tsukuda, Asao Katsume, Yuko Aoki, Takuya Umehara, Satoshi Sekiguchi, Tetsuya Toyoda, Kunitada Shimotohno, Tomoyoshi Soga, Masahiro Nishijima, Ryo Taguchi, Michinori Kohara
Self-Enhancement of Hepatitis C Virus Replication by Promotion of Specific Sphingolipid Biosynthesis
PLoS Pathogens August 2012 Volume.8 Issue.8 e1002860

Qiang Wang, Leiyun Weng, Hongbing Jiang, Shijian Zhang, Tetsuya Toyoda
Fluorescent primer-based in vitro transcription system of viral RNA-dependent RNA polymerases
http://dx.doi.org/10.1016/j.ab.2012.10.025

Akatsu H, Ogawa N, Kanesaka T, Taniguchi C, Mimuro M, Yoshida M, Matsuyama Z, Kurihara R, Kohashi O, Hori A, Yamamoto T, Hashizume Y.
Multiple findings in elderly adults with confirmed Alzheimer's disease.
J Am Geriatr Soc. 2012 Nov;60(11):2169-70.

Yokota T, Akatsu H, Miyauchi T, Heese K.
Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.
FEBS Lett. 2012 Dec 14;586(24):4357-61.

Weng L, Tian X, Gao Y, Watashi K, Shimotohno K, Wakita T, Kohara M, Toyoda T.
Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro.
Biochim Biophys Acta. 2012 Dec;1820(12):1886-92.

Sako W, Ito H, Yoshida M, Koizumi H, Kamada M, Fujita K, Hashizume Y, Izumi Y, Kaji R.
Nuclear factor κ B expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations.
Clin Neuropathol. 2012 Nov-Dec;31(6):418-23.

TOPへ 

 
2013年

Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K.
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA.
EMBO Mol Med. 2013 Feb;5(2):221-34.

Akitake Y, Nakatani Y, Kamei D, Hosokawa M, Akatsu H, Uematsu S, Akira S, Kudo I, Hara S, Takahashi M.
Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model.
J Neurosci Res. 2013 Jul;91(7):909-19. doi: 10.1002/jnr.23217. Epub 2013 Mar 29.

Wen Y, Miyashita A, Kitamura N, Tsukie T, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Akatsu H, Yamamoto T, Kosaka K, Yamaguchi H, Akazawa K, Ihara Y, Kuwano R.
SORL1 is Genetically Associated with Neuropathologically Characterized Late-Onset Alzheimer's Disease.
J Alzheimers Dis. 2013;35(2):387-94.

井之上浩一,赤津裕康,豊岡利正
展望 認知症の分析科学的アプローチ
「ぶんせき」  日本分析化学会 機関誌 3月号:132.2013

Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I; Alzheimer Disease Genetics Consortium, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R.
SORL1 Is Genetically Associated with Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians.
PLoS One. 2013;8(4):e58618. doi: 10.1371/journal.pone.0058618. Epub 2013 Apr 2.

Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J, Probst A, Winkler DT, Reichwald J, Staufenbiel M, Ghetti B, Goedert M, Tolnay M.
Brain homogenates from human tauopathies induce tau inclusions in mouse brain.
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9535-40.

Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M.
Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains.
Cell Rep. 2013 Jul 11;4(1):124-34.

Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I; The Alzheimer Disease Genetics Consortium, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R.
Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians.
PLoS One. 2013 Jul 8;8(7).

Inoue K, Tsutsui H, Akatsu H, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T.
Metabolic profiling of Alzheimer's disease brains.
Sci Rep. 2013 Aug 6;3:2364.

Kuru S, Sakai M, Yoshida M, Mimuro M, Hashizume Y.
Neurofibrillary tangles in the peripheral sympathetic ganglia of patients with myotonic dystrophy.
Neuropathol Appl Neurobiol. 2013 Aug;39(5):585-8.

Okamura N, Furumoto S, Harada R, Tago T, Yoshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Yamamoto T, Arai H, Iwata R, Yanai K, Kudo Y.
Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease.
J Nucl Med. 2013 Aug;54(8):1420-7.

堀 映、秋山治彦
脳銃創
神経科学(Clin Neurosci) 31(4) 384-385 2013

Manavalan A, Mishra M, Feng L, Sze SK, Akatsu H, Heese K.
Brain site-specific proteome changes in aging-related dementia.
Exp Mol Med. 2013 Sep 6;45:e39.

Datta A, Akatsu H, Heese K, Sze SK.
Quantitative clinical proteomic study of autopsied human infarcted brain specimens to elucidate the deregulated pathways in ischemic stroke pathology.
J Proteomics. 2013 Sep 2;91C:556-568.

赤津裕康
高齢者の栄養障害 2)慢性期病棟における栄養状態とその管理
栄養-評価と治療 30(3): 202 -205 2013

赤津裕康
長期療養型病床における高齢者の栄養管理
治療が劇的にうまくいく!「高齢者の栄養」はじめの一歩 大村健二、葛谷雅文/編 第4章2項 羊土社 2013

Akatsu H, Iwabuchi N, Xiao JZ, Matsuyama Z, Kurihara R, Okuda K, Yamamoto T, Maruyama M.
Clinical Effects of Probiotic Bifidobacterium longum BB536 on Immune Function and Intestinal Microbiota in Elderly Patients Receiving Enteral Tube Feeding.
JPEN J Parenter Enteral Nutr. 2013 Sep;37(5):631-40.

Akatsu H, Arakawa K, Yamamoto T, Kanematsu T, Matsukawa N, Ohara H, Maruyama M.
Lactobacillus in Jelly Enhances the Effect of Influenza Vaccination in Elderly Individuals.
J Am Geriatr Soc. 2013 Oct;61(10):1828-1830.


TOPへ 

 
2014年

ten Donkelaar HJ, Bekker M, Renier WB, Hori A, Shiota K:
Clinical Neuroembryology: Development and developmental disorders of the human central nervous system. 2nd Edition, Chapter 4. Neurulation and Neural Tube Defects.
Springer, Heidelberg - New York - Dordrecht - London, 2014 pp165-217

ten Donkelaar HJ, Itoh K, Hori A:
Chapter 6. Development and Developmental Disorders of the Spinal Cord.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical Neuroembryology: Development and developmental disorders of the human central nervous system. 2nd Edition, Springer, Heidelberg - New York - Dordrecht - London, 2014 pp271-320

ten Donkelaar HJ, Lammens M, Weseling P, Hori A:
Chapter 8. Development and Developmental Disorders of the Human Cerebellum.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical Neuroembryology: Development and developmental disorders of the human central nervous system. 2nd Edition, Springer, Heidelberg - New York - Dordrecht - London, 2014 pp371-420

ten Donkelaar HJ, Lammens M, Cruysberg JRM, Kamphuis-van Ulzen K, Hori A, Shiota K:
Chapter 9. Development and Developmental Disorders of the Forebrain.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical Neuroembryology: Development and developmental disorders of the human central nervous system. 2nd Edition, Springer, Heidelberg - New York - Dordrecht - London, 2014 pp421-521

ten Donkelaar HJ, Lammens M, Aronica E, van Bokhoven H, Kamphuis-van Ulzen K, Hori A:
Chapter 10. Development and Developmental Disorders of the Cerebral Cortex.
In: ten Donkelaar HJ, Lammens M, Hori A: Clinical Neuroembryology: Development and developmental disorders of the human central nervous system. 2nd Edition, Springer, Heidelberg - New York - Dordrecht - London, 2014 pp523-642

Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T.
Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissues by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry.
Anal Chem. 2014 Jan 7;86(1):797-804.

Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Morishima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T.
Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.
J Alzheimers Dis. 2014;39(4):861-70.

Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M.
Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2638-43.

Mizoi M, Yoshida M, Saiki R, Waragai M, Uemura K, Akatsu H, Kashiwagi K, Igarashi K.
Distinction between mild cognitive impairment and Alzheimer's disease by CSF amyloid β40 and β42, and protein-conjugated acrolein.
Clin Chim Acta. 2014 Mar 20;430:150-5.

Miyashita A, Wen Y, Kitamura N, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Furukawa K, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Nishizawa M, Suga M, Kawase Y, Akatsu H, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Yamaguchi H, Akazawa K, Kanazawa I, Ihara Y, Ikeuchi T, Kuwano R.
Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.
J Alzheimers Dis. 2014;41(4):1031-8.

Uhm KO, Kim MJ, Kawaguchi M, Akatsu H, Miura Y, Misumi S, Hida H, Choi EK, Kim YS, Michikawa M, Jung CG.
ATBF1 is a Novel Amyloid-β Protein Precursor (AβPP) Binding Protein that Affects AβPP Expression.
J Alzheimers Dis. 2014 Jul 30.

Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M.
Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathies.
Ann Clin Transl Neurol. 2014 Jul 3;1(7):479-489.

Yuki D, Sugiura Y, Zaima N, Akatsu H, Takei S, Yao I, Maesako M, Kinoshita A, Yamamoto T, Kon R, Sugiyama K, Setou M.
DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease.
Sci Rep. 2014 Nov 20;4:7130.


TOPへ 

 
2015年

Inoue K, Tsuchiya H, Takayama T, Akatsu H, Hashizume Y, Yamamoto T, Matsukawa N, Toyo'oka T.
Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis.
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:24-34.

Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I.
Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.
Neurosci Lett. 2015 Mar 30;591:19-24. doi: 10.1016/j.neulet.2015.02.013. Epub 2015 Feb 9.

Jin JK, Jang B, Jin HT, Choi EK, Jung CG, Akatsu H, Kim JI, Carp RI, Kim YS.
Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.
PLoS One. 2015 Apr 13;10(4):e0122120.

Nagafuchi S, Yamaji T, Kawashima A, Saito Y, Takahashi T, Yamamoto T, Maruyama M, Akatsu H.
Effects of a Formula Containing Two Types of Prebiotics, Bifidogenic Growth Stimulator and Galacto-oligosaccharide, and Fermented Milk Products on Intestinal Microbiota and Antibody Response to Influenza Vaccine in Elderly Patients: A Randomized Controlled Trial.
Pharmaceuticals (Basel). 2015 Jun 18;8(2):351-65. doi: 10.3390/ph8020351.

Sabri O, Sabbagh MN, Seibyl J, Barthel H, Akatsu H, Ouchi Y, Senda K, Murayama S, Ishii K, Takao M, Beach TG, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Catafau AM, Stephens AW, Mueller A, Koglin N, Hoffmann A, Roth K, Reininger C, Schulz-Schaeffer WJ; Florbetaben Phase 3 Study Group.
Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: phase 3 study.
Alzheimers Dement. 2015 Aug;11(8):964-74. doi: 10.1016/j.jalz.2015.02.004. Epub 2015 Mar 28.

Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S.
A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.
Psychiatr Genet. 2015 Aug;25(4):139-46. doi: 10.1097/YPG.0000000000000090.

Takayama T, Mochizuki T, Todoroki K, Min JZ, Mizuno H, Inoue K, Akatsu H, Noge I, Toyo'oka T.
A novel approach for LC-MS/MS-based chiral metabolomics fingerprinting and chiral metabolomics extraction using a pair of enantiomers of chiral derivatization reagents.
Anal Chim Acta. 2015 Oct 22;898:73-84. doi: 10.1016/j.aca.2015.10.010. Epub 2015 Oct 22.

Manabe T, Mizukami K, Akatsu H, Teramoto S, Yamaoka K, Nakamura S, Ohkubo T, Kudo K, Hizawa N.
Influence of pneumonia complications on the prognosis of patients with autopsy-confirmed Alzheimer's disease, dementia with Lewy bodies, and vascular dementia.
Psychogeriatrics. 2015 Oct 29. doi: 10.1111/psyg.12163. [Epub ahead of print]


TOPへ 

 
2016年


Ishiguro M, Okada A, Asai K, Kojima K, Okada H.
Stimulation of neuronal cells by culture supernatant of T lymphocytes triggered by anti-CD3 mAb followed by propagation in the presence of IL-2.
Microbiol Immunol. 2016 Jan;60(1):47-55.

Akatsu H, Nagafuchi S, Kurihara R, Okuda K, Kanesaka T, Ogawa N, Kanematsu T, Takasugi S, Yamaji T, Takami M, Yamamoto T, Ohara H, Maruyama M.
Enhanced vaccination effect against influenza by prebiotics in elderly patients receiving enteral nutrition.
Geriatr Gerontol Int. 2016 Feb;16(2):205-13.

Ochiishi T, Itakura A, Liu L, Akatsu H, Kohno H, Nishimura M, Yoshimune K.
Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-β aggregates.
Genes Cells. 2016 Feb;21(2):200-11.

Kametani F, Obi T, Shishido T, Akatsu H, Murayama S, Saito Y, Yoshida M, Hasegawa M.
Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.
Sci Rep. 2016 Mar 16;6:23281.

Mizukami K, Akatsu H, Abrahamson EE, Mi Z, Ikonomovic MD.
Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.
Neuropathology. 2016 Apr;36(2):135-45.

赤津裕康
アルツハイマー病:補体との関わり
医学のあゆみ 特集 補体関連疾患の新局面vol 257, No8P.849-853(2016.5)

Seibyl J, Catafau AM, Barthel H, Ishii K, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Takao M, Akatsu H, Murayama S, Bullich S, Mueller A, Koglin N, Schulz-Schaeffer WJ, Hoffmann A, Sabbagh MN, Stephens AW, Sabri O.
Impact of Training Method on the Robustness of the Visual Assessment of 18F-Florbetaben PET Scans: Results from a Phase-3 Study.
J Nucl Med. 2016 Jun;57(6):900-6.

Liu L, Watanabe N, Akatsu H, Nishimura M.
Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.
Neuroscience. 2016 Aug 25;330:236-46.

Kawaguchi M, Hara N, Bilim V, Koike H, Suzuki M, Kim TS, Gao N, Dong Y, Zhang S, Fujinawa Y, Yamamoto O, Ito H, Tomita Y, Naruse Y, Sakamaki A, Ishii Y, Tsuneyama K, Inoue M, Itoh J, Yasuda M, Sakata N, Jung CG, Kanazawa S, Akatsu H, Minato H, Nojima T, Asai K, Miura Y.
A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression.
BMC Cancer. 2016 Oct 18;16(1):805.

Manabe T, Mizukami K, Akatsu H, Hashizume Y, Teramoto S, Nakamura S, Kudo K, Hizawa N.
Prognostic Factors Related to Dementia with Lewy Bodies Complicated with Pneumonia: An Autopsy Study.
Intern Med. 2016;55(19):2771-2776. Epub 2016 Oct 1.

Hino M, Kunii Y, Matsumoto J, Wada A, Nagaoka A, Niwa S, Takahashi H, Kakita A, Akatsu H, Hashizume Y, Yamamoto S, Yabe H.
Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.
J Psychiatr Res. 2016 Nov;82:100-8.


TOPへ 

 
2017年


Vu HT, Akatsu H, Hashizume Y, Setou M, Ikegami K.
Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.
Sci Rep. 2017 Jan 9;7:40205.

Sabbagh MN, Schäuble B, Anand K, Richards D, Murayama S, Akatsu H, Takao M, Rowe CC, Masters CL, Barthel H, Gertz HJ, Peters O, Rasgon N, Jovalekic A, Sabri O, Schulz-Schaeffer WJ, Seibyl J.
Histopathology and Florbetaben PET in Patients Incorrectly Diagnosed with Alzheimer's Disease.
J Alzheimers Dis. 2017;56(2):441-446.

Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S.
Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.
J Proteomics. 2017 Mar 31;158:31-42.